I've just worked around this for a while, but it's plenty annoying. If I pause my music, lock the computer, and am gone long enough for the screen to shut off (maybe?), the play button no longer responds and I have to refresh the browser to play music again. I'm not 100% certain what might trigger this issue, as perhaps it's something to do with a CPU state, but regardless, it's very consistent and repeatable. Windows 10 1809 LTSC & Chrome (various versions over past ... six months)
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